Detailed Notes on mif

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MIF has also been shown to directly bind to chemokine receptors CXCR2 and CXCR4, which control inflammation and cell migration by means of the PI3K/Akt and ERK1/two pathways [47]. Moreover, CXCR2 and CXCR4 are also ready to form receptor complexes with CD74 and can be internalized together with CD74 just after conversation with MIF, which also brings about activation with the PI3K/Akt and ERK1/2 pathways [47–49]. Theoretically, most chemokines bind to their receptors by way of a two-internet site binding involving the N-like loop and Glu-Leu-Arg (ELR) motif.

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